High-Intensity Focused Ultrasound Increases Collagen and Elastin Fiber Synthesis by Modulating Caveolin-1 in Aging Skin

High-Intensity Focused Ultrasound Increases Collagen and Elastin Fiber Synthesis by Modulating Caveolin-1 in Aging Skin

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Caveolin-1 (Cav-1) induces cellular senescence by reducing extracellular signal-regulated kinase (ERK)1/2 phosphorylation and activating p53 via inhibition Travel Mug of mouse double minute 2 homolog (MDM2) and sirtuin 1 (Sirt1), promoting cell cycle arrest and decreasing fibroblast proliferation and collagen synthesis.High-intensity focused ultrasound (HIFU) treatment increases collagen synthesis, rejuvenating skin.Using H2O2-induced senescent fibroblasts and the skin of 12-month-old mice, we tested the hypothesis that HIFU increases collagen production through Cav-1 modulation.HIFU was administered at 0.3, 0.

5, or 0.7 J in the LINEAR and DOT modes.In both models, HIFU administration decreased Cav-1 levels, increased ERK1/2 phosphorylation, and decreased the Waxed Gilets binding of Cav-1 with both MDM2 and Sirt1.HIFU administration decreased p53 activation (acetylated p53) and p21 levels and increased cyclin D1, cyclin-dependent kinase 2, and proliferating cell nuclear antigen levels in both models.HIFU treatment increased collagen and elastin expression, collagen fiber accumulation, and elastin fiber density in aging skin, with 0.

5 J in LINEAR mode resulting in the most prominent effects.HIFU treatment increased collagen synthesis to levels similar to those in Cav-1-silenced senescent fibroblasts.Our results suggest that HIFU administration increases dermal collagen and elastin fibers in aging skin via Cav-1 modulation and reduced p53 activity.